In a large mixing bowl, combine 1 pound of ground beef with 2 tablespoons of Cajun seasoning, 1 teaspoon of garlic powder, 1 teaspoon of onion powder, and a generous pinch of salt and pepper. Mix until just combined and form into 4 patties.

Preheat your grill or skillet over medium-high heat (about 400°F). Add oil or butter if using a skillet.

Carefully place the patties onto the hot surface. Cook for 4-5 minutes without pressing down, then flip and cook for another 3-4 minutes until achieving an internal temperature of 160°F.

Top each patty with a slice of smoked cheese during the last minute of cooking, covering to melt the cheese.

Butter the insides of the buns and toast them on the grill or skillet for 1-2 minutes.

To assemble, spread sauce on the bottom bun, add the patty, and layer with toppings. Finish with the top bun and serve immediately.