In a large skillet, heat over medium-high heat and add the lean ground beef. Cook for 5-7 minutes, breaking it apart with a spatula until browned and cooked through. Stir in garlic powder, onion powder, Italian seasoning, salt, and black pepper.

Once the ground beef is browned, remove the skillet from heat. Transfer the meat to a plate using a slotted spoon, leaving excess grease in the pan.

In a medium mixing bowl, combine sour cream, ketchup, soy sauce, garlic powder, onion powder, and maple syrup. Whisk until smooth and well-blended.

Layer the romaine lettuce in serving bowls, spoon the cooked ground beef on top, and add slices of avocado, red onion, pickles, and cherry tomatoes.

Drizzle the burger sauce over the assembled ingredients, season with salt and pepper to taste.